Co-overexpression of SWEET sucrose transporters modulates sucrose synthesis and defence responses to enhance immunity against bacterial blight in rice.

Enhancing carbohydrate export from source to sink tissues is considered to be a realistic approach for improving photosynthetic efficiency and crop yield. The rice sucrose transporters OsSUT1, OsSWEET11a and OsSWEET14 contribute to sucrose phloem loading and seed filling. Crucially, Xanthomonas oryzae pv. oryzae (Xoo) infection in rice enhances the expression of OsSWEET11a and OsSWEET14 genes, and causes leaf blight. Here we show that co-overexpression of OsSUT1, OsSWEET11a and OsSWEET14 in rice reduced sucrose synthesis and transport leading to lower growth and yield but reduced susceptibility to Xoo relative to controls. The immunity-related hypersensitive response (HR) was enhanced in the transformed lines as indicated by the increased expression of defence genes, higher salicylic acid content and presence of HR lesions on the leaves. The results suggest that the increased expression of OsSWEET11a and OsSWEET14 in rice is perceived as a pathogen (Xoo) attack that triggers HR and results in constitutive activation of plant defences that are related to the signalling pathways of pathogen starvation. These findings provide a mechanistic basis for the trade-off between plant growth and immunity because decreased susceptibility against Xoo compromised plant growth and yield.

Medication Adherence and its Predictors among Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study.

Medication adherence is vital in managing noncommunicable diseases like diabetes. Illness perception and an individual's knowledge regarding the disease may influence medication adherence. The present study aimed to assess the prevalence and predictors of medication adherence among type 2 diabetic patients. A cross-sectional study was conducted among 400 diabetes mellitus patients attending an outdoor patient department (OPD) of a tertiary care hospital in North India. Brief Medication Questionnaire (BMQ) and Brief Illness Perception Questionnaire (B-IPQ) were used to study medication adherence and illness perception, respectively. Descriptive and analytic statistics were computed using Epi Info software for Windows (CDC, Atlanta, GA, USA). The prevalence of medication adherence was 79.5% (82/400). The odds of medication adherence increased with higher age (odds ratio [OR] = 1.8 [1.1-2.9]) and more duration of illness (OR = 1.8 [1.0-3.2]) Patients having good knowledge of diabetes were more likely to adhere to medications. [OR=1.8(1.1-3.1). Diabetes medicine-adherent patients had a higher perceived understanding of the disease, felt having lesser negative consequences, and were less concerned about the illness than their counterparts. A high proportion adhered to diabetes medication. The guiding factors to further improve medication adherence are age, duration of illness, illness perception, and knowledge regarding the disease.

Assessment of the risk of developing type 2 diabetes using the Indian diabetes risk score in an urban community in Chandigarh, India: A cross-sectional study.

BACKGROUND: The urban poor is a group that is known to be vulnerable to the adoption of a more urbanized lifestyle that places them at a higher risk for diabetes. Identification of at-risk individuals using simple screening tools like the Indian diabetes risk score developed by Madras Diabetes Research Foundation (MDRF-IDRS) and appropriate lifestyle interventions could greatly help in preventing or postponing the onset of diabetes and thus reducing the burden of the disease on the community and the nation as a whole. MATERIALS AND METHODS: A cross-sectional study was conducted on individuals ≥30 years (n = 1533) of both genders in an urban colony of Chandigarh during a period of 1 year. A stratified two-stage systematic random sampling was adopted. The risk of developing Type 2 diabetes mellitus was assessed using IDRS. The total risk score of each participant was analyzed and compared. Biochemical investigations, including blood glucose and lipid profiles for detecting diabetes, were conducted. Data were presented in percentages and proportions. The statistical analysis of the data was performed by using the Chi-square test and logistic regression analysis. RESULTS: The prevalence of diabetes was 3.1% in the present study. Overall, the mean IDRS was found to be 52.14 ± 16.01. Elderly persons aged 60 years and above had higher IDRS. IDRS showed significant variability with age (P < 0.001). Females had significantly higher IDRS as compared to males (P = 0.002). The association between socioeconomic class and risk status was highly significant statistically (P < 0.001). IDRS among individuals with diabetes was found to be significantly higher (64.29 ± 13.92) as compared to non-diabetics. Among all, 749 (48.7%) had high IDRS, whereas 54 (3.5%) had low IDRS. There were 734 (47.8%) with moderate IDRS. CONCLUSION: IDRS was found to be highly sensitive for detecting the risk of diabetes, suggesting its potential use as a screening tool in community setup for the purpose of detecting diabetes.

Prevalence and predictors of low bone mineral density among adults aged 50 years and above in Chandigarh, India.

Background: Osteoporosis, defined as skeletal disorder characterized by reduced bone density and strength, is prevalent in both developing and developed countries. Dual energy X-ray absorptiometry (DEXA) is an effective tool to diagnose low bone mineral density (BMD). Objective: This study objective was to know the prevalence and predictors of low BMD in a community-based screening program among the adult population using DEXA scan. Methods: In this community-based study conducted between January and June 2016, a population-based screening program was offered to both males and females of age 50 years and above. BMD was measured to derive T-scores and classify as normal, osteopenic, and osteoporotic individuals. Results: A total of 455 subjects were enrolled where 62.4% proportion was women; 42.6% subjects were in the age group of 50 to 59 years. The prevalence of osteoporosis and osteopenia was 20.9% and 48.1%, respectively. Hypertension (23.7%) and diabetes (8.4%) were common comorbidities. Age and gender (female) were independent predictors of low BMD. Conclusion: Osteoporosis/osteopenia is present in both genders with increasing trend with age advancement. Institution of timely screening will prevent the morbidity associated with fractures due to low BMD.

Introducing Communication Skills Training among Interns using Attitude, Ethics, and Communication Module.

Background: Communication skills are the backbone for patient care services such as patient interviews, counseling the patient, and explaining treatment options. The present study was conceived to evaluate the communication training program and perceptions of medical interns and faculty regarding the same. Methodology: Sixty medical interns were included in this cross-sectional study. Training on communication skills was imparted which was later assessed on the basis of Kalamazoo scale. Attitude of the interns regarding communication skill training was assessed using Rees and Sheard Scale. The attitude of faculty regarding introduction of communication skill was also assessed. Results: The mean score on Kalamazoo Consensus Scale was 19.65 ± 4.97 with a range of 10-29. Females had a higher score (21.09 ± 5.80) as compared to males (17.88 ± 3.21), but this was not statistically significant (P = 0.157). The mean score for positive and negative attitude scale was 59.15 ± 5.51 and 25.20 ± 9.60. Conclusion: The ability to communicate effectively is a core competency expected of medical graduates and communication skills training of medical students and interns with the help of didactic lectures, role plays, and videos, etc., can go a long way in improving their communication skills.

A cross-sectional study to assess the pre-marital sexual practices among Panjab University students, Chandigarh, India.

Background: In India, premarital partnerships whether involving sex or not are widely unacceptable. Various studies in India have reported heightened premarital sexual activities among youngsters. Objective: The objective of the study was to assess the involvement of youth in premarital sexual practices studying at Panjab University. Methods: The cross-sectional study was conducted at Panjab University situated in Chandigarh, India between February and August 2020. Purposive sampling was used to recruit students. Data was collected using a pre-tested, semi-structured, self-administered questionnaire. The nature of the data was quantitative and was analyzed through SPSS version 20. Results: A total of 211 (female/male: 51.7%/48.3%, mean age: 22.5 years) respondents were enrolled. Prevalence of premarital sex was 68.7% with an average age of sexual debut 18.5 years. 62.1% of respondents were practicing unprotected sex. 91% of respondents were involved in vaginal sex, 61.4% in oral sex, 29% in online sex, and 19.3% in anal sex. 66.8% of respondents were involved in the habit of masturbation. In students having a positive premarital sexual background, 78.2% of respondents had sexting, 38.8% had friends with benefits, 33.9% had one-night stands, 4.8% had a threesome and 2.3% had gay sex. Out of all the respondents involved in premarital sexual practices, 86.9% were satisfied with sexual life. Conclusion: There is a need to empower the younger population involved in risky sexual behavior by accelerating their sexual and reproductive rights education to propagate safe sexual behavior in premarital sexual practices.

Contraceptive awareness and practices in reproductive age couples: A study from urban slums of Punjab.

Introduction: Developing countries are characterised by high birth rates and explosive population growth. With a lower contraceptive usage rate among eligible couples and resistance towards family planning methods, the goal of population stabilisation looks distant. The present study was conceived to assess knowledge, attitude and practices regarding contraceptive usage and to identify the barriers in reproductive-age couples in an urban slum area. Methods: The present study was cross-sectional in nature and was conducted in an urban slum. Three hundred married subjects were enrolled through a convenient sampling technique. One member of the married couple was interviewed for the present study. Data were collected through a semi-structured proforma. Results: 67% of the participants were using one or another contraceptive. Higher contraceptive usage was seen in more educated participants. Awareness was higher in males regarding contraception. Condom was the most known method for contraception. Three fourth of the participants agreed with two-child norm. Preference for a male child was less than 50% in both genders. Current users of condoms and oral contraceptive pills were 71.8% and 7.1%, respectively. Wanting children, fear of side effects and lack of knowledge were cited as reasons for not choosing family planning methods. Conclusion: With a suboptimal level of awareness and attitude among respondents regarding contraceptive methods, there exists a gap between awareness and practice. Misconceptions regarding contraceptive methods can be allayed through health education, involvement of the community and religious leaders and peer counselling.

Prevalence and Predictors of Physical Inactivity among Adults - A Cross-Sectional Study.

Background: Physical inactivity is detrimental to health. It is a risk factor for noncommunicable diseases. Aim and Objective: The aim of this study was to find the prevalence and predictors of physical inactivity among adults. Methodology: A cross-sectional community-based study was conducted among 374 adults aged 20-50 years. Trained field investigators administered the Global Physical Activity Questionnaire. Data were analyzed using Epi Info software for Windows. Logistic regression model was used to study the factors associated with physical inactivity. Results: The prevalence of physical inactivity among the study participants was 52.1%. Females (OR=1.9[1.2-3.1]), literate individuals (OR = 1.8 [1.04-3.2]), and current tobacco users (OR = 2.2 [1.8-4.1]) were significantly more physically inactive; as compared to their counterparts. Conclusions: Nearly half of the study participants were physically inactive, according to the World Health Organization guidelines. This highlights the need for strengthening the existing interventions for promoting physical activity among adults.

Stress, Coping, and Resilience Among Home-Quarantined Persons During the COVID-19 Pandemic: Findings From a Community Study.

Objective: To assess stress, coping, and resilience among home-quarantined individuals via a community survey during the coronavirus disease 2019 (COVID-19) pandemic.Methods: In this cross-sectional study, a combined list was generated of all contacts of positive COVID-19 cases, traced by a contact tracing team, and international travelers who had entered the country after March 8, 2020 (2 weeks before the air travel shutdown on March 22, 2020 in India). This community-based study was conducted among people who were quarantined in their homes and international travelers who arrived in the country after declaration of lockdown. Stress and coping were assessed via the 12-item General Health Questionnaire, 10-item Perceived Stress Scale, and Brief Resilient Coping Scale. The participants with higher perceived stress scores (≥ 14) were asked to seek help from telemedicine services. Study data were collected from April 8, 2020, to May 20, 2020.Results: The mean age of the 153 study participants was 40.10 years, and 41.8% were women. Poor coping was identified in 25.5% of the sample, and moderate/high stress was present in 49.7%. Significantly higher stress was noted in women (P = .007). Higher age, joint family structure, and contacts of COVID cases were significant predictors of moderate/severe perceived stress in the logistic regression.Conclusions: Adequate psychological supportive services should be provided to home-quarantined persons through provision of information, rapid communication, and timely supplies of general and medical items.

Prevalence and predictors of self-reported risk behaviors among male injecting drug users.

BACKGROUND: Unsafe injecting drug use is a documented risk factor for the transmission of human immunodeficiency virus infection. Harm reduction strategy aims at reducing this deleterious consequence. OBJECTIVES: To study the prevalence and predictors of injecting as well as sexual risk behavior among male injecting drug users (IDUs). METHODS: A cross-sectional study was conducted among 250 male IDUs from January 2017 to March 2018. Risk behavioral data were collected after obtaining informed consent of the study participants. This included information on sharing, reusing needles/injections, and sexual behavior. Descriptive statistics and logistic regression model was run using the Epi Info software version 7.2 for Windows. RESULTS: In the past one month, 25.3% had shared needles/syringes by either borrowing or lending or both. Inconsistent condom use during sexual intercourse with a regular, casual, and paid sex partner was practiced by 64.7% (77/119), 65.8% (48/73), and 45.0% (18/40), respectively. The binary logistic regression analysis revealed that unsafe injecting drug behavior was higher among daily users: (OR = 3.0 [1.3-6.6]) and comparatively lower among those who preferred to avail needles/syringes from Needle Syringe Exchange Program (OR = 0.4 [0.2-0.9]); as compared to their counterparts. CONCLUSIONS: The findings suggest that IDUs in the study area are engaging in risk behaviors. Behavior change communication and harm reduction strategy should be strengthened.

Prevalence of reproductive tract infection symptoms and treatment-seeking behavior among women: A community-based study.

INTRODUCTION: Reproductive tract infection (RTI) is a public health problem affecting women's health, especially in developing country like India. The associated stigma with this reproductive morbidity is often a deterrent in seeking health care. AIMS AND OBJECTIVES: The aim was to study the prevalence of RTI symptoms and treatment-seeking behavior among married women of reproductive age group. METHODOLOGY: It was a community-based cross-sectional study. A total of 276 women were interviewed in the community by trained medical social workers. RTI symptoms were defined according to the syndromic case management guideline developed by the World Health Organization. Statistical analysis was performed using the Epi Info software for Windows (CDC Atlanta). RESULTS: About one-third (98/276; 35.5%) of women reported symptoms suggestive of RTI. The most commonly experienced symptoms were foul-smelling vaginal discharge (68/98; 69.4%) followed by lower abdominal pain not associated with menstruation (51/98; 52.0%). Around half of those having RTI symptoms sought treatment for their problem (57.1%). CONCLUSION: Health-care professionals in India should focus on strengthening women knowledge of RTI symptoms and encouraging them to seek health care.

Prevalence of Diabetes Mellitus and its Predictors among Tuberculosis Patients Currently on Treatment.

BACKGROUND: Tuberculosis (TB) and diabetes are the world's leading public health issues. They are the cause of morbidity, mortality, and pose a burden on the healthcare system. AIMS AND OBJECTIVES: The aim and objective of this study were to study the prevalence of diabetes and its predictors among TB patients currently on treatment. The secondary objective was to examine the self-reported blood glucose monitoring and antidiabetic drug adherence practice among diabetic TB patients. METHODOLOGY: This cross-sectional study was undertaken on 275 TB cases enrolled from selected designated microscopy centers. Self-reported information on diabetes, tobacco usage, and family history of TB was collected by trained investigators. In addition, for diabetic tubercular patients, the study investigators inquired about the type of treatment taken (allopathic/traditional), frequency of getting blood sugar tested, and daily drug adherence. For comparison between the "diabetes TB comorbidity" and "TB only group," Chi-square test of significance was used, and odds ratios were reported. Data were analyzed using Epi Info software (CDC Atlanta). RESULTS: The prevalence of diabetes among TB patients was found to be 13.1% (known diabetics -9.1% and new diabetics -4.0%). There were 25.5% of current/former smokers (70/275) and 13.1% of current/former smokeless tobacco users (36/275). In logistic regression analysis, age 50 years and above emerged as a significant predictor for diabetes TB comorbidity (adjusted odds ratio = 9.8 [4.3-22.3]). CONCLUSION: Diabetes is prevalent comorbidity in TB patients. Age more than 50 years significantly increases the odds of this twin morbidity.

Prevalence of Depression, Anxiety and Stress among school going adolescent in Chandigarh.

CONTEXT: Depressive disorders often start at a young age. There is a need for early identification of depression, anxiety, and stress (DAS) and prevention. The present study was undertaken to find the magnitude of DAS among adolescents. AIMS: To find the mental health status of school going adolescents in Chandigarh. The objectives were (i) to study the prevalence of DAS among school going adolescents and (ii) to study the correlates of DAS. SETTINGS AND DESIGN: A Cross-sectional survey of students of four classes from 9th to 12th studying in government schools. SUBJECTS AND METHODS: Ten government schools in Chandigarh were randomly selected through lottery method. In each school, for each of the four classes, a section was randomly selected again by the lottery method. Forty students were selected from each school reaching sample size of 470. DAS scale 21 questionnaires were used. STATISTICAL ANALYSIS USED: The data entry was done in MS Office Excel 2007. The analysis was done in the form of frequency tables, charts cross tables. For statistical significance, Chi-square test and correlation was found between various factors. RESULTS: The prevalence of DAS was 65.53%, 80.85%, and 47.02%, respectively. Overall, comorbidity between depression and anxiety was 57.65%. Extremely severe depression was very less (3%). The prevalence of DAS was higher in females. For depression and anxiety, the peak age was 18 years. CONCLUSIONS: The prevalence of DAS was high among school going adolescents in Chandigarh. There is a need for early and effective identification of DAS that can prevent many psychiatric disorders at their nascent stage.

Sexual behavior of adolescent students in Chandigarh and their perceptions regarding family life education.

BACKGROUND: With rapidly changing lifestyle and exposure to the Internet and mass media, lifestyle and sexual behavior of adolescent students are also changing rapidly. OBJECTIVES: To investigate the sexual behavior of adolescent students and to study misconceptions prevailing among them. METHODS: A cross-sectional survey of 1022 adolescent students aged 14-19 years as a part of an Indian Council of Medical Research sponsored survey. Sexual behavior explored by interview method. Logistic regression analysis for finding correlates. RESULTS: Intimate friendship was reported by 19.2% respondents. The sexual behavior included 89% exposure to sex-related material, 74.7% were aware of sexual intercourse. Awareness regarding at least one contraceptive was found among 95.5% (94.5% of condoms and 67.2% of emergency contraception). About 6% respondents reported some sex-related problems and 2.5% of all respondents consulted some doctors for these problems. Awareness of HIV/AIDS was quite high (about 99%), and 96.4% of them were of the opinion that it is spread through sexual intercourse. Knowledge regarding transmission of sexually transmitted infections (STIs) through sexual contact was found among 89.2% respondents. Avoidance/abstinence from sex (84.7%), faithful to one partner (81.7), and use of barrier methods (90.3%) was main reported preventive measures for STI's. About 33% want that the discussion about sex should be open and frank, and 69.4% showed the need of sex education in the schools mostly by doctors. CONCLUSIONS: Sexual behavior of adolescent students is changing, and awareness about sex acts is also increasing. There is likelihood of indulging in risky behavior by adolescents. Family life education was felt necessary mainly by qualified medical staff.

Complementary and alternative medicine use among the cancer patients in Northern India.

BACKGROUND: Cancer has emerged as a major public health problem. People often turn to complementary and alternative medicine (CAM) when they have a long-lasting problem. CAM is a group of diverse medical and healthcare systems, practices, and products that are not generally considered part of conventional medicine. The present study was conducted to find prevalence rate of CAM use among cancer patients undergoing allopathic treatment in a health facility and to compare the CAM usage patterns among different subgroups of patients at different stages. Further to investigate some psychosocial, cultural, and demographiccorrelates/predictors of CAM use. MATERIALS AND METHODS: Present hospital-based cross sectional study was conducted among cancer patients attending Radiotherapy Outpatient Department (OPD) of a Government Medical College and Hospital (GMCH). A total of 1,117 cancer patients participated in the study. Statistical methods like normal test of proportions, Chi-square (χ(2)) test, logistic regression analysis for estimation of risk factors of CAM use were applied to carry out the data analyses using Statistical Package for Social Sciences (SPSS)-16 software package. RESULTS: The most common CAM therapy in use was found to be ayurvedic treatment reported by 187 (16.7%) patients. Overall CAM use was found to be 38.7%. Sixty percent of patients who were aware of CAM were not using CAM, only 40% aware were using CAM. Low socioeconomic status contributed maximum to proportions of CAM use; wherein out of all users, 175 (40.5%) patients were using CAM. Maximum degree of relief was found due to homeopathic treatment (78.4%). Reasons of using CAM therapies reported by the users were mainly on the advice of family members or friends (23.1%). CONCLUSIONS: There is an urgent need of conducting further in-depth epidemiological studies to evaluate the efficacy of various CAM therapies in use for cancer. The high utilization of CAM among cancer patients and nondisclosure proportions suggests prioritizing research investigating reasons to use CAM and efficacy and safety of CAM use.

Surveillance of bacteriological quality of drinking water in Chandigarh, northern India.

The study was carried out in Chandigarh, India with the following objectives: (1) to monitor the bacteriological quality of drinking water; (2) to collect data on bacteriological contamination of water collected at point of use; (3) to test both groundwater being supplied through hand pumps and pre-treated water; and (4) to determine the pattern of seasonal variations in quality of water. The community-based longitudinal study was carried out from 2002 to 2007. Water samples from hand pumps and tap water were collected from different areas of Chandigarh following a simple random sampling strategy. The time trends and seasonal variations in contamination of water according to area and season were analysed. It was found that the contamination of water was higher during the pre-monsoon period compared with the rest of the year. The water being used in slums and rural areas for drinking purposes also had higher contamination levels than urban areas, with highest levels in rural areas. This study found that drinking water supply in Chandigarh is susceptible to contamination especially in rural areas and during pre-monsoon. Active intervention from public health and the health department along with raising people's awareness regarding water hygiene are required for improving the quality of drinking water.

Gender disparities in retreatment patients of tuberculosis: A north Indian study.

BACKGROUND: 'Retreatment' for tuberculosis (TB) has long been a neglected area in global TB control India. However India disproportionately accounts for nearly half of retreatment TB cases notified globally. Sex differences vary in different age groups and in different parts of the world. The present study focuses on whether gender-based differences are present in notification rates, clinical presentation, and treatment outcomes of different subcategories of patients registered under category II of Revised National TB Control Programme (RNTCP) Chandigarh. MATERIALS AND METHODS: A longitudinal study was designed and the patients registered under RNTCP category II from June 2010 to December 2011. Out of total 607 patients registered during this period under category II of RNTCP in Chandigarh, 545 consented to participate in the study. These were followed-up to September 2012 till the completion of treatment. All 545 recruited cases were stratified into males and females and the results analyzed. The Z test for proportion (for comparing differences in proportions) and Student's t-test (for comparing mean) were performed for statistical analysis. RESULTS: From the cohort of 545 patients, 348 (63.9%) were males and 197 (36.1%) were female patients with overall male to female ratio 1.8:1. The proportion of male patients notified was significantly higher than females (Z = 5.93, P < 0.001). The proportion of extrapulmonary cases was higher in the females (28.4%) as compared with males (17%) (P < 0.001). Males outnumbered females in all the unfavorable outcomes death, default, and failure. The default in males was significant as compared to the females (Z = 5.21, P < 0.001). CONCLUSIONS: The findings of this study suggest a sex difference in the notification rate of retreatment cases of TB. Reasons for a better outcome and low notification rate for TB in females are more due to epidemiological factors than a differential access of the health care. Integrated research is required to outline the relative roles played by epidemiology.

Reasons for interruption of anti-tubercular treatment among the retreatment patients in category II of RNTCP in Chandigarh, north India.

INTRODUCTION: More re-treatment TB patients are notified in India than any other country in the world, and default among this group is a serious public health problem. Adherence to the long course of TB treatment is a complex, dynamic phenomenon with a wide range of factors impacting on treatment taking behaviour. The main aim of the study was to study the basic clinical and demographic profile of the defaulters and the reasons for discontinuation of treatment among these retreatment patients in category II of RNTCP. METHODS: A longitudinal study was designed and the patients registered under RNTCP category II from June 2010 to December 2011 at various centres in Chandigarh formed the study cohort. Out of total 607 patients registered during this period under category II of RNTCP in Chandigarh, 545 consented to participate in the study. These were followed up to September 2012 till the completion of treatment. 32 patients among the registered 545 defaulted from the treatment during the period. These patients were traced in the community and information regarding reasons for interruption and barriers to treatment was obtained from them using a pre-structured pre-tested questionnaire. Data were analysed using SPSS 18 statistical software package. RESULTS: 32(5.9%) patients defaulted from the treatment under RNTCP category II. 29(90.6%) were pulmonary patients while 3(9.4%) were extra-pulmonary patients. 46.9% of the defaulters were in the age group of 20-35 years, followed by 31.3% in the age group of 36-50 years. 21.9% went to traditional healers for cure while 12.5% tried herbal medicine during the treatment. 25% (eight) patients did not have faith on the DOTS treatment. Most common side effects of treatment complained by the patients were GI upset (62.5%), fatigue (59.4%), drowsiness (34.4%) and itching (31.3%). 46.8% believed that ATT induced side-effects were the main reason for treatment interruption. Maximum treatment interruption was seen at the end of the third month (31.3%). CONCLUSIONS: Maximum interruptions were found to occur by end of third month of ATI. AT" induced side-effects were the main reason for treatment interruption. Efforts need to be made to improve the pre-treatment counselling, increase proportion of patients treated by community-based DOTS providers, repeated health education to the patients emphasizing the need to continue treatment.

Treatment Outcome Among the Retreatment Tuberculosis (TB) Patients under RNTCP in Chandigarh, India.

BACKGROUND: 'RETREATMENT' for Tuberculosis (TB) has long been a neglected area in global TB control. While other components of the Stop TB Strategy have garnered appropriate focus and, increasingly, sufficient resources, issues related to the TB of patients previously treated for tuberculosis remain under examined and under-resourced. METHODS: A longitudinal study was designed and the patients registered under Revised National Tuberculosis Control Programme (RNTCP) category II from June 2010 to December 2011.Out of total 607 patients registered during this period under category II of RNTCP in Chandigarh (India), 545 consented to participate in the study. These were followed up to September 2012 till the completion of treatment. STATISTICAL ANALYSIS: The analysis was done by using SPPS-18 statistical software package. Chi- square test was used for testing association of different characteristics. RESULTS: Four Hundred Thirty (78.9%) of the patients had pulmonary TB and 115(21.1%) of the patients had extra pulmonary TB. In the study cohort of category II patients 264(48.4%) were relapse patients,167(30.6%) belonged to others category, 75(13.8%) were on treatment after default, 39(7.2%) were failure cases. The mean age of patients was 35.92 ± 15.42 (p = 0.928). Maximum patients belonged to age group of 25-34 years (25.3%). Seventy Three (13.4%) were Illiterate. In treatment after default group only 65.3% patients were cured. Maximum deaths 8% were seen in treatment after default group of patients. The overall default in the study was 5.9%. CONCLUSION: The findings of this study suggest that it is essential to monitor re-treatment patients with same vigour to reduce default and improve their treatment outcome.